Oxygen Therapy Contraindications:
Hyperbaric oxygen therapy (HBOT) involves breathing pure oxygen in a pressurized chamber to enhance oxygen delivery to tissues, promoting healing and recovery. While HBOT offers significant benefits for various medical conditions, it’s crucial to recognize that certain individuals should avoid this therapy due to specific contraindications. This article explores the absolute and relative contraindications, additional considerations, and who should avoid HBOT to ensure patient safety and optimal treatment outcomes.
Absolute Contraindications (HBOT Should Not Be Performed)
Untreated Pneumothorax
An untreated pneumothorax, where air accumulates between the lung and chest wall causing lung collapse, is an absolute contraindication to HBOT. Introducing such a patient to a pressurized environment can lead to a life-threatening tension pneumothorax. Therefore, it is imperative to diagnose and treat the pneumothorax before considering HBOT. A chest X-ray is usually required to rule out this condition before starting treatment.

Certain Chemotherapy Drugs
Patients undergoing chemotherapy with Doxorubicin (Adriamycin) or Cisplatin should avoid HBOT, as high levels of oxygen can amplify the toxicity of these drugs, leading to severe side effects. Medical professionals assess the patient’s treatment plan before recommending HBOT.
Recent or Ongoing Radiation Therapy
Individuals receiving or having recently completed radiation therapy may experience radiation-induced tissue damage when combined with HBOT. The therapy can exacerbate complications such as fibrosis and vascular damage, potentially worsening the condition instead of aiding recovery.
Uncontrolled High Fever
A high fever can intensify metabolic activity, leading to complications when exposed to HBOT. The therapy may further elevate body temperature, increasing the risk of hyperthermia-related issues. It is advisable to stabilize body temperature before starting HBOT. .
Relative Contraindications (HBOT May Be Performed with Caution)
Pulmonary Conditions
Patients with certain lung diseases, such as chronic obstructive pulmonary disease (COPD) with air trapping, may have an increased risk of complications like pneumothorax during HBOT. The high levels of oxygen can lead to absorption atelectasis, a condition where alveoli collapse due to nitrogen displacement. A thorough pulmonary assessment, including lung function tests, is crucial before initiating therapy.
Upper Respiratory Infections
Conditions like colds, sinus infections, or respiratory congestion can impede the ability to equalize ear and sinus pressures during HBOT, leading to discomfort, ear pain, or even barotrauma. Patients are advised to resolve these infections before undergoing treatment to avoid complications. In some cases, decongestants or antihistamines may be recommended to ease symptoms before therapy.

Recent Ear or Thoracic Surgery
Individuals who have recently undergone ear, sinus, or chest surgeries may be at heightened risk for complications during HBOT. Pressure changes can cause discomfort, exacerbate healing issues, or disrupt surgical repairs. A detailed medical history and consultation with a physician are necessary to evaluate the safety of proceeding with therapy. In some cases, post-operative patients may need to wait several weeks before they are eligible for HBOT.
Claustrophobia
Since HBOT requires patients to be in a confined chamber for extended periods, individuals with claustrophobia may experience significant anxiety, making the therapy challenging. Some facilities offer larger, multi-person chambers to accommodate patients who may feel uncomfortable in enclosed spaces. Additionally, relaxation techniques or mild sedation may be used to help patients manage their anxiety.
Additional Considerations
Seizure Disorders
Individuals with a history of seizures should be carefully evaluated, as HBOT can, in rare cases, induce oxygen toxicity seizures due to high oxygen concentrations. This risk can be mitigated by controlling predisposing factors such as fever, anxiety, and low blood sugar before treatment. Some patients may be given anticonvulsant medication as a precaution.
Pregnancy
While not an absolute contraindication, the use of HBOT during pregnancy requires careful consideration and should be evaluated on a case-by-case basis. Some studies suggest potential risks to fetal development, while others indicate that HBOT may be beneficial in cases of severe anemia or carbon monoxide poisoning. Pregnant women should consult a specialist to determine the safest course of action.
Who Should Avoid HBOT?
While HBOT is generally safe for most people, the following groups should avoid or undergo careful evaluation before proceeding with treatment:
- Individuals with untreated pneumothorax – The risk of lung collapse under pressure makes this an absolute contraindication.
- Patients with severe COPD or other pulmonary conditions – These individuals are at higher risk of complications such as air trapping or pneumothorax.
- Individuals prone to seizures – HBOT can, in rare cases, induce oxygen toxicity seizures, particularly in those with predisposing conditions.
- Pregnant women (without medical approval) – While not an absolute contraindication, HBOT during pregnancy should be carefully considered based on medical necessity.
- People with severe claustrophobia – If not managed properly, anxiety in the chamber can lead to treatment difficulties.
- Patients recovering from recent ear, sinus, or thoracic surgery – Healing tissues may be vulnerable to pressure-related complications.
- Individuals with active upper respiratory infections or fever – These conditions can cause discomfort and potential complications during HBOT.
Conclusion
Understanding both absolute and relative contraindications to hyperbaric oxygen therapy is essential for ensuring patient safety and optimizing treatment outcomes. A comprehensive medical evaluation is necessary to identify potential risks and make informed decisions regarding the appropriateness of HBOT for each individual.
If you are looking for professional and high-quality HBOT services, Lakeshore Hyperbaric Chicago provides expert care tailored to individual needs. Contact us today to learn more about how hyperbaric oxygen therapy can benefit you.
Disclaimer: This article is for informational purposes only and should not replace professional medical advice. Always consult a healthcare provider before starting any new medical treatment.